Fig. 3
Abplatin(IV) inhibited tumor growth on a PDXHCC model. A Schematic illustration showing the establishment of a PDXHCC model for in vivo studies. B In vivo biodistribution of Abplatin(IV) labeled with Cy7.5 via in vivo imaging and ex vivo imaging of major organs at 36 h. C The corresponding semi-quantification of the fluorescence signal of Abplatin(IV) over time and biodistribution of major organs. D Tumor growth inhibition curves of mice treated with PBS, cisplatin, and Abplatin(IV). E H&E staining and TUNEL of representative tumor tissues. Scale bar for H&E images = 200 µm, scale bar for TUNEL images = 100 µm. F H&E staining of major organs of mice treated by PBS and Abplatin(IV), scale bar = 100 µm