Fig. 8

Fluorescence intensities of major organs from SARS-CoV-2-N transfected mice. A SARS-CoV-2 infected mouse model with p-SARS-CoV-2-N@ZIF-8 were established. A SEM characterization of ZIF-8 nanoparticles; B SEM characterization of pEOFP-N1-N@ZIF-8 nano-composites; C The size distributions of ZIF-8 and pEOFP-N1-N@ZIF-8 particles in PBS (10 mM, pH 7.4). D UV-vis absorption spectra of nanoparticles among ZIF-8, pEOFP-N1-N and pEOFP-N1-N@ZIF-8 particles, which support pEOFP-N1-N has been coated into ZIF-8. E The fluorescence measurements on SARS-CoV-2-N were detected at tissue level. The fluorescence signals indicated that different distribution of SARS-CoV-2-N gene among major organs. No significant enhanced signals were found on normal tissue