Fig. 3
The uptake of CsA@HFn in OGD/R injured SH-SY5Y cells and penetration BBB efficiency of CsA@HFn. A The protein expression of TfR1 in OGD/R injured SH-SY5Y cells and bEnd3 cells. B The uptake of CsA@HFn in OGD/R injured SH-SY5Y cells. C The uptake mechanism of CsA@HFn in OGD/R injured SH-SY5Y cells. D The resistance values between transwell recipient chamber and donor chamber within 12 h after drug administration. E The penetration in vitro BBB efficiency of CsA@HFn. F The distribution of CsA@HFn in brain tissue of MCAO mice. G The distribution of CsA@HFn in infarcted area and normal area of MCAO mice (green color stands for nanoparticle, and red color stands for blood vessel). (n = 3, x ̅±SD, **P < 0.01)