Fig. 3
From: Nanoparticles mediated tumor microenvironment modulation: current advances and applications
Copyright 2011 by Alili [31]. b (i) SPION conjugated with relaxin-2 (RLX), (ii) photographs shows the effect of different concentrations of RLX on human PSCs when activating with 5 ng TGF-β relative contraction quantification is presented in bar diagram) and corresponding migration of human PSCs and relative wound healings are presented in Fig. (iii). Copyright 2018 by Mardhian [32]. c Schematic demonstrates the strategy for targeting the central part of TME and selectively disrupted α-SMA expression in the tumor core, destabilizing the internal core and eradicating tumor cells without affecting the outer stroma. Copyright 2019 by Chen [34]. d Gene transfection of siWnt NPs in in vitro studies. Copyright 2018 by Miao [35]. e Schematic illustrates the involved mechanism in targeting TAFs for ablating the tumor and reshaping the TME by reprogramming the CAFs. Copyright 2017 by Huang [36]
Destruction/targeting of CAFs: a (i) CeO2 morphology and corresponding fluorescent micrographs (a–d) cellular uptake of nanoceria, and (e–f) FITC-labelled nanoceria in human dermal fibroblasts (e) and sqauamous tumor cells (f), and (ii) TGFβ1-mediated mRNA expression of αSMA confirmed the downregulation after treated with nanoceria.