Fig. 6

Disrupting the tumor vasculature using VDAs: a (i) Schematic illustrates the synthesis of RGD@HCuS with N₂ bubble generation and corresponding TEM images of HCuS nanoparticles and RGD@HCuS nanomedicine.(ii) intra cellular localization of RGD@HCuS nanomedicine and (iii) targeted mechanism for the tumar vasculature destruction using NIR laser activated bomb-like effect. Copyright 2019 by Gao [48]. b (i) Synthesis approach of RPTDH/R848 nanoparticles and (ii) schematic establishment of the mechanism involved in suppression of growth and metastasis in breast cancer cells. Copyright 2019 by Zhou [51]. c (i) Schematic representation of the development of artificial RBCM coated PFC@PLGA nanoparticles and corresponding TEM images of PFC@PLGA and PFC@PLGA@RBCM nanoparticles, (ii) quantification of oxygen from the PFC@PLGA@RBCM nanoparticles added water with and without applying the pressure and (iii) in vivo radiotherapy and corresponding effect on the tumor growth. Copyright 2017 by Gao [52]. d (i) Schematic shows the ultrasound induced local oxygenation with nano-PFC, (ii) photoacoustic imaging established oxygenated and deoxygenated hemoglobin by irradiating with 850 and 750 nm, respectively, (iii)oxyhemoglobin quantification in the tumor, (iv) schematic representation of the ultrasound activated nano-PFCs generated tumor oxygenation enhanced PDT, (v) tumor growth curves and (vi) corresponding tumor weights after different PDT treatments. Copyright 2016 by Song [53]