Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Zhuang, Danping; Zhang, Huifen; Hu, Genwen; Guo, Bing

doi:10.1186/s12951-022-01479-6

Journal of Nanobiotechnology

Table 1 Contrast agents for MRI and multimodal imaging modalities

From: Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Materials	Targeting moiety	Tumor model	Imaging method	References
Fe₃O₄ (MNP)	MT	Orthotopic C6 mice model	MRI(T2)	[62]
Lf-SPION	Lf	Orthotopic C6 mice model	MRI(T2)	[63]
HPF-NSCs	NSCs	Orthotopic U251T.eGFP.ffluc mice model	MRI(T2)	[64]
NPCP-BG-CTX	CTX and CED	Orthotopic GBM6-luc mice model	MRI(T2)	[65]
MGMSPID	Interleukin-13	Orthotopic U251 mice model	MRI(T2)	[66]
M-HFn	HFn	Orthotopic U87MG mice model	MRI(T2)	[67]
SPION-EGF	EGF	Orthotopic C6 mice model	MRI(T2)	[68]
Rhodamine-Mfls	MT	Orthotopic U87MG mice model	MRI(T2)	[69]
SPION-Hsp70	Hsp70	Orthotopic 9 L mice model	MRI(T2)	[70]
SD-MD	MT	Orthotopic C6 mice model	MRI(T2)	[71]
CARD-B6	B6	Orthotopic U87MG mice model	MRI(T2)	[72]
RGD-magnetosomes	RGD	Orthotopic U87MG mice model	MRI(T2)	[73]
CLIO-ICT	ICT2588	Orthotopic pcGBM39 mice model	MRI(T2)	[74]
ND-MMSNS	Neutrophils	Orthotopic U87-Luc/C6-Luc mice model	MRI(T2)	[75]
RGE-Exo-SPION/Cur	RGE	Orthotopic U251 mice model	MRI(T2)	[76]
NPCP-CTX	CTX and CED	Orthotopic GBM6 mice model	MRI(T2)	[77]
Ang-LiB(T + AN@siTGF-β)	Ang	Orthotopic GL261 mice model	MRI(T2)	[78]
IUdR/NGO/SPION/PLGA	MT	Orthotopic C6 mice model	MRI(T2)	[79]
I6P7-SPIO	I6P7	Orthotopic U87MG mice model	MRI(T2)	[80]
USPIO-PEG-tLyP-1	tLyP-1	Orthotopic U87MG mice model	MRI(T2)	[81]
PTPu-IO	PTPu	Orthotopic U87MG mice model	MRI(T2)	[82]
GrB-SPION	GrB	Orthotopic C6 mice model	MRI(T2)	[83]
NP-MTX-CTX	CTX	Subcutaneous 9 L mice model	MRI(T2)	[84]
NP-PEG-CTX	CTX	Subcutaneous 9 L mice model	MRI(T2)	[85]
MPGNPs	–	Subcutaneous C6 mice model	MRI(T2)	[86]
Fe₃O₄@Au-C225	C225	Subcutaneous U251 mice model	MRI(T2)	[87]
Gd-DTPA-DGLs-PEG-CTX	CTX	Orthotopic C6 mice model	MRI(T1)	[88]
DPC-DTPA-Gd	CD	Orthotopic U87MG mice model	MRI(T1)	[42]
Gd-NGO/Let-7 g/EPI	–	Orthotopic U87MG mice model	MRI(T1)	[89]
Au@DTDTPA-Gd	–	Orthotopic 9LGS mice model	MRI(T1)	[90]
Gd₃N@C₈₀(OH)_x(NH₂)_y((amino-1))	Interleukin-13	Orthotopic U251 mice model	MRI(T1)	[91]
iRPPA@TMZ/MnO	iRGD	Orthotopic C6 mice model	MRI(T1)	[92]
Den-RGD-Reg + Gd³⁺-DTPA	RGD and Regadenoson	Orthotopic U87MG mice model	MRI(T1)	[93]
NaGdF4-TAT-labeled T cell	T cell	Orthotopic GL261 mice model	MRI(T1)	[94]
HA-MnO₂	HA	Orthotopic C6 mice model	MRI(T1)	[95]
CPP-2	Ang	Orthotopic C6 mice model	MRI(T1)	[96]
MnO₂@Tf-ppIX	Tf	Orthotopic C6 mice model	MRI(T1)	[37]
AGuIX@PS@KDKPPR	KDKPPR	Orthotopic U87MG mice model	MRI(T1)	[97]
Fe₃O₄-ANG	ANG	Orthotopic U87L mice model	MRI(T1)	[98]
M-CSTD.NHAC/Cu(II)	RGD and DER	Orthotopic C6 mice model	MRI(T1)	[99]
Pt/MnO₂@PVCL NGs	Macrophage membrane	Orthotopic C6 mice model	MRI(T1)	[56]
HB-POEGMA-cRGD-Gd	cRGD	Subcutaneous U87MG mice model	MRI(T1)	[100]
rUCNPs@HSA(Ce6-Mn)-RGD	RGD	Subcutaneous U87MG mice model	MRI(T1)	[101]
Mn-ZIF-8/5-Fu	–	Subcutaneous U87MG mice model	MRI(T1)	[102]
Cu₂(OH)PO₄@PAA	–	Subcutaneous U251 mice model	MRI(T1)	[103]
PFC-labeled CAR T	CAR T	Subcutaneous U87-EGFRvIII-Luc mice model	¹⁹F MRI	[104]
TAT-PFC- labeled CAR T	CAR T	Subcutaneous U87-EGFRvIII-Luc mice model	¹⁹F MRI	[105]
G5-SA-D-Ac	CED	Orthotopic U87MG mice model	CEST-MRI	[106]
YbHPDO3A	–	Orthotopic U87MG mice model	CEST-MRI	[107]
Fe_0.6Mn_0.4O	–	Orthotopic U87MG mice model	MRI(T1/T2)	[108]
Fe-NCP	–	Orthotopic GL261 mice model	MRI(T1/T2)	[109]
Mn-NEB + BSA	–	Orthotopic U87MG mice model	MRI(T1/T2)	[110]
NP-S-S-PEP	RGD	Orthotopic U87MG mice model	MRI(T1/T2)	[111]
Fe₃O₄@SiO₂@mSiO₂/DOX-(Gd-DTPA)-PEG-RGE	RGE	Subcutaneous U87MG mice model	MRI(T1/T2)	[112]
D@HMON@FG@R2	RGD	Subcutaneous U87MG mice model	MRI(T1/T2)	[113]
POP/DCM@P-Mn-SPIO	–	Orthotopic 12FLR mice model	TMRET(T1/T2)	[114]
PFOB	RGD	Orthotopic U87MG mice model	¹⁹ F MRI/FI	[115]
Au-AZ/Au-AK	ANG	Orthotopic U87MG mice model	MRI(T1)/Raman	[116]
Cy5.5-Lf-MPNA	Lf	Orthotopic C6 mice model	MRI(T2)/FI	[117]
FluoroMags	–	Orthotopic GBM-NSs mice model	MRI(T2)/FI	[118]
QSC-Lip	MT	Orthotopic C6 mice model	MRI(T2)/FI	[119]
SPIO@DSPE-PEG/DOX/ICG	–	Orthotopic C6 mice model	MRI(T2)/FI	[120]
BFNP	–	Subcutaneous C6 mice model	MRI(T2)/FI	[121]
ICG-SPIO	–	Subcutaneous U251 mice model	MRI(T2)/PAI	[122]
Tb-doped MnCO₃	–	Orthotopic C6 mice model	MRI(T1)/photoluminescence	[123]
CTX-NaGdF₄:Ho³⁺	CTX	Orthotopic C6 mice model	MRI(T1)/FI	[124]
P/Gd-DTPA/cetuximab/MsTfR-mAb/Alexa-680	cetuximab/MsTfR-mAb	Orthotopic EGFR⁺U87MG mice model	MRI(T1)/FI	[125]
MnO	–	Orthotopic C6 mice model	MRI(T1)/FI	[126]
NCDDG	–	Orthotopic U87MG mice model	MRI(T1)/FI	[127]
Gd-Ag₂S	–	Orthotopic U87MG mice model	MRI(T1)/NIR-II FI	[128]
CH4T@MOF-PEG-AE	AE105	Orthotopic U87MG mice model	MRI(T2)/NIR-II FI	[129]
Den RGD-Angio	RGD	Orthotopic U87MG mice model	MRI(T1)/NIR FI	[130]
Gd/MnCO₃-PEG-Cy5.5-FA	FA	Orthotopic C6 mice model	MRI(T1)/NIR FI	[131]
MnO-PEG-Cy55	–	Orthotopic C6 mice model	MRI(T1)/NIR FI	[132]
ICG-FA-PPC	FA	Subcutaneous U87MG mice model	MRI(T1)/NIR FI	[133]
Cy5.5-Lf-SPIO	Lf	Orthotopic C6 mice model	MRI(T2)/NIR FI	[134]
Cy5.5-Fe₃O₄-PEG-RGD-FA	RGD and FA	Orthotopic C6 mice model	MRI(T2)/NIR FI	[135]
^DANG/Cy7-SPIONs	^DANG	Orthotopic Luc-U87MG mice model	MRI(T2)/NIR FI	[38]
NPC-Cy5.5	CTX	9 L cell	MRI(T2)/NIR FI	[136]
⁶⁴Cu-DOTA-IO-RGD	RGD	Subcutaneous U87MG mice model	MRI(T2)/PET	[137]
Gd@C82-Ala-PEG-cRGD-(NOTA-⁶⁴Cu or ⁸⁹Zr)	cRGD	Subcutaneous U87MG mice model	MRI(T1)/PET	[138]
⁶⁴Cu-cRGD-SPIO	RGD	Subcutaneous U87MG mice model	MRI(T2)/PET	[139]
¹²⁵I-RGD-PEG-MNPs	RGD	Subcutaneous U87MG mice model	MRI(T2)/SPECT	[140]
RGD-Au-Mn DENPs	RGD	Orthotopic C6 mice model	MRI(T1)/CT	[141]
MPR	–	Orthotopic eGFP⁺ U87MG mice model	MRI(T1)/PAI/Raman	[142]
MSC-HA-MSNs-Gd³⁺-⁶⁴Cu-ZW800	MSC	Orthotopic U87MG mice model	MRI(T1)/PET/NIR	[143]
HALF-cRGD	cRGD	Orthotopic C6 mice model	MRI(T2)/PAI/FI	[144]
cRGD-CM-CPIO	cRGD	Orthotopic C6 mice model	MRI(T2)/PAI/FI	[145]
Au@MIL-88(Fe)	–	Orthotopic U87MG mice model	MRI(T2)/CT/PAI	[146]
Fe₃O₄@Au	α_vβ₃ mAb	U87MG cell	MRI(T2)/CT/PAI	[147]
Gd-PEG-Bi	–	Subcutaneous U87MG mice model	MRI(T1)/CT/PAI	[148]
⁶⁴Cu-Fe-RGD-PEG-MNP	RGD	Subcutaneous U87MG mice model	MRI(T1)/PET/PAI	[149]

Back to article page

ISSN: 1477-3155

Contact us

Submission enquiries: journalsubmissions@springernature.com