Fig. 3From: Dual-binding nanoparticles improve the killing effect of T cells on solid tumorMagnetic responsiveness of DBMN-T in vivo. A Schematic diagram of a bilateral tumor model on the back of mouse. B Fluorescence images of DiR-labeled DBMN-T rearrangement in vivo under the magnetic field for 48 h photographed by IVIS system. Pink circle, under magnetic field; Blue circle, without magnetic field. C Fluorescence semi-quantitative result of (B) by software in IVIS system. D The ratio of the fluorescence intensity of the magnetic field to the opposite side at the same mouse, n = 4. Blank, no magnetic field effect, the default is 1. E Representative immunofluorescence images of labeled T cells in tumor and (F) is semi-quantitative fluorescence of (E) by Image J. G Representative Prussian blue staining images of tumor. Yellow arrows indicate the position of blue plaques and the number was shown in (H) counted by Image J. Scale bar, 100 μm. Plus M means external magnetic field. Statistical analyses were carried out by Prism graphpad 8.0. All error bars are expressed as ± SD. Comparisons between two or several groups were analyzed using unpaired Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001Back to article page