Scheme 1.
From: Biomimetic nanobubbles for triple-negative breast cancer targeted ultrasound molecular imaging
Tumor-targeted NBs. a Conventional targeted NBs produced by lipid film hydration functionalized with a cancer specific ligand (NBligand). The ligand can be conjugated on a pre-formed bubble (top), or, to one element constituting the shell before bubble formation (bottom); b CCM-based NB for US molecular imaging of TNBC developed in this study, with c its representative structure, and d its mechanism of tumor targeting across endothelial junctions