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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity

Fig. 7

Protective effects on auditory function in guinea pigs and underlying mechanisms. A ABR thresholds of various groups. *** p < 0.001 control vs CDDP (Day 1) and CDDP (Day 3), # p < 0.05 ATX-PPS-NP + CDDP (Day 1) vs CDDP (Day 1), ## p < 0.01 ATX-PPS-NP + CDDP (Day 1) vs CDDP (Day 1), & p < 0.05 ATX-PPS-NP + CDDP (Day 1) vs ATX + CDDP (Day 1) B & D. H&E staining of SGNs and calculations of SGN density in 2–4 turns of guinea pig cochleae. * p < 0.05 vs control, ** p < 0.01 vs control, *** p < 0.001 vs control, # p < 0.05 vs CDDP. C & E. Immunohistochemistry of 4-HNE in SGNs and quantifications of integrated optical density (IOD) of 4-HNE staining. *** p < 0.001 vs control, ## p < 0.01 vs CDDP

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Journal of Nanobiotechnology

ISSN: 1477-3155

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