Fig. 6

Effect of TGF-β signaling and LANP-PTX-siSRI in reversal cancer chemoresistance. a Expression of Smad2 and P-Smad2 in chemoresistant A2780/PTX and A549/PTX cells was detected by Western blot. b–c Expression of SRI protein in A2780/PTX and A549/PTX after TGF-β administration was detected by Western blot. d–e Expression of SRI mRNA after TGF-β administration was detected by qRT-PCR. f The concentration of calcium ions in A2780/PTX and A549/PTX after TGF-β administration was detected by flow cytometry. g–h Fluorescence intensity reflected calcium ion concentration in A2780/PTX (g) and A549/PTX (h) after TGF-β administration was detected by flow cytometry. i Schematic illustration of LANP-PTX-siSRI in reversal cancer chemoresistance