Fig. 6

P/LLL/AP2/rh nanoconjugates for BBB penetration. a Chemical composition of P/LLL/AP2/rh, optical imaging data showing nanoconjugate permeation of the cerebral cortex (A_1-3) and average nanoconjugate fluorescence in brain parenchyma (B_1-3). b Pharmacokinetics of nanoconjugate in serum (P/LLL/AP2/rh and P/LLL/rh) and brain tissue (optical imaging of the sagittal sinus blood vessel). c Vascular fluorescence intensity profile (right) for the sagittal sinus vessel as indicated with a yellow line (only 30 min drug accumulation shown in the left). d Time dependence of nanoconjugate fluorescence intensity in brain parenchyma. Reprinted from ref. [107], with permission from the American Chemical Society, Copyright 2019