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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Photoluminescent carbon dots (PCDs) from sour apple: a biocompatible nanomaterial for preventing UHMWPE wear-particle induced osteolysis via modulating Chemerin/ChemR23 and SIRT1 signaling pathway and its bioimaging application

Fig. 4

a Tartrate-resistant acid phosphatase (TRAP) staining images reveal the effect of PCDs treatment on UHMWPE-induced osteoclast differentiation at different concentrations. Herein, the TRAP-positive cells with more than three nuclei, which were counted to be usual osteoclasts. The graphs representing the (b) number of osteoclasts, (c) their area of percentage, and (d) relative osteoclastogenesis genes in the experimental groups. The number of osteoclasts was counted using ImageJ software. Data are represented as mean ± SD; * indicates P < 0.05 compared with normal control and # indicates P < 0.05 compared with the UHMWPE group to PCD-treated groups

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Journal of Nanobiotechnology

ISSN: 1477-3155

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