Fig. 7

Effect of ITGBL1 protein on fibroblast and skin tissue. A Protein levels of ITGBL1 in CHDFs transfected with ITGBL1. n = 3. B mRNA levels of COL1A1 in CHDFs transfected with ITGBL1. n = 3. C Proliferation of CHDFs transfected with ITGBL1. n = 3. Scare bar = 100 μm. D Cell cycle of CHDFs transfected with ITGBL1. Data are the percentage of G1, G2/M and S. n = 3. E Wound recovery area of CHDFs treated with ITGBL1. Objective area is between the two red lines. n = 3. F Images of collagen gel contraction in CHDFs treated with ITGBL1. n = 3. Skin thickness (G) and collagen I content (H) of mice injected ITGBL1 vectors. n = 3. I Protein levels of the related genes in CHDFs treated with ITGBL1. n = 3. Data was calculated using student’s t test and two-way ANOVA followed by Bonferroni’s multiple comparisons test. Data are expressed as means ± SEM; with P* < 0.05, P** < 0.005, P*** < 0.001