Fig. 5From: Multistage nucleic acid amplification induced nano-aggregation for 3D hotspots-improved SERS detection of circulating miRNAsApplicability of detection. A Representative SERS spectra obtained from the detection of 1 pM miRNA-499 in TE buffer and in serum. B Comparison of SERS peak intensities at 1340 cm−1 of miRNA-499 at different concentrations in TE buffer and in serumBack to article page