Fig. 2

RCM-fiber-BMMSCs accelerate wound closure in diabetic mouse. A Experiment designing for diabetes induction followed by wound regeneration and healing processes. Mice were fed with high-fat and high sugar diets, and diabetes was induced by intraperitoneal injection of streptozocin. The wounds were made after 4 weeks of diabetes induction, and wound closure was studied in 2 weeks upon the treatment. B Representative images of the wounds at day 0, 5, 10 and 15 post-wounding, respectively. C Quantification of the residual wound areas at day 0, 5, 10 and 15, respectively. D Representative images of H&E staining for the wounds at day 15 (left) with high-resolution images of epidermis, dermis and hypodermis (right). Scale bar = 1 mm (left) or 50 μm (right). E Quantification of average epidermal thickness of the wounds. Data were represented as mean ± SD. Differences were assessed by using two-way analysis of variance (ANOVA) with Tukey’s multiple comparison tests and one-way ANOVA with Tukey’s multiple comparison tests. (mice: n ≥ 8) NS: non-significant, *P < 0.05, **P < 0.01