Fig. 8

TCM-fiber-hBMMSCs improve wound healing in diabetic mice. A Representative images of the wound areas at day 0, 5, 10 and 15 post-wounding, respectively. B Quantification of residual wound areas at day 0, 5, 10 and 15, respectively. C Representative images of H&E staining for the wound areas at day 15 (left) with high-resolution images of epidermis, dermis and hypodermis (right). Scale bar = 1 mm (left) or 50 μm (right). D Quantification of average epidermal thickness of the wound areas. E Masson’s trichrome staining for tissue sections (left) with high-resolution images of collagen deposition in the epidermis, dermis and hypodermis (right) in diabetic mouse wounds. Scale bar = 1 mm (left) or 50 μm (right). F Picrosirius red staining for collagen deposition in the wound areas from diabetic mice. Scale bar = 50 μm. G Comparisons of Collagen 1 and Collagen 3 proportions in the wound areas among different groups. Data were represented as mean ± SD. Differences were analyzed through two-way and one-way ANOVA with Tukey’s multiple comparison tests. (mice: n ≥ 8) NS: non-significant, *P < 0.05, **P < 0.01