Scheme 1

LPS/IFN-γ activated RAW264.7 cell (M1-like murine macrophage cell) membrane modified PLGA nanofibers with BMMSCs attachment promote diabetic wound healing. The RCM-fiber-BMMSCs accelerate wound closure with rapid re-epithelialization, collagen remodeling, immunoregulation, antioxidant stress and angiogenesis in experimental diabetic wound healing in vivo. This is partially achieved through CD200-CD200R axis accompanied by the upregulation of Lcn2, TNFAIP6, Lif and Ccl2 in BMMSCs. The RCM-fiber-BMMSCs function as a living material with in situ immunostimulatory capacity to exaggerate the biofunctions of BMMSCs