Fig. 5

Pathways involved in the tubuloid changes promoted by CM-OAT1 and EV-OAT1. a Representative scheme of the comparison of proteins exclusively upregulated in tubuloids cultured with CM-OAT1 or EV-OAT1. b The Venn diagram shows the upregulated proteins in the tubuloids incubated with CM-OAT1 or EV-OAT1 as compared to tubuloids cultured under standard differentiation protocol. c The graph indicates the biological processes associated with the commonly upregulated proteins in tubuloids cultured with CM-OAT1 or EV-OAT1. d The graph indicates the biological pathways associated with the commonly upregulated proteins in tubuloids cultured with CM-OAT1 or EV-OAT1. The abscissa indicates − Log10(p-value). e Representative scheme of the comparison of proteins exclusively downregulated in tubuloids cultured with CM-OAT1 or EV-OAT1. f The Venn diagram shows the downregulated proteins in the tubuloids incubated with CM-OAT1 or EV-OAT1 compared to tubuloids cultured under standard differentiation protocol. g The graph indicates the biological processes associated with the commonly downregulated proteins in tubuloids cultured with CM-OAT1 or EV-OAT1. h The graph indicates the biological pathways associated with the commonly downregulated proteins in tubuloids cultured with CM-OAT1 or EV-OAT1. The abscissa indicates − Log10(p-value)