Fig. 5
a Singlet oxygen generation of PSMA NPs loaded with YI series dyes by RNO/imidazole assay under 10 min of 660 (solid lines) and 808 (dotted lines) nm laser irradiation (75 mW/cm2 and 0.9 W/cm2, respectively). b PDT efficacy of PSMA-242, PSMA-YI-1, and PSMA-ADF1 NPs in MB49 cancer cells under 808 nm laser irradiation (0.9 W/cm2) for 10 min. c Schematic of the in vivo treatment process. d Ultrasound images of a mouse bladder with tumors before and after treatment with PBS and CPBA-conjugated PSMA-YI-1 NPs combined with 30 min of 660 nm laser irradiation (75 mW/cm2). Scale bar = 2 mm. e Tumor area changes quantified from d. (*p < 0.05, compared with PBS group)