Fig. 4

The regulation of PEP@GO-sEVs and miR-21 mimic in the treatment of HUVECs with HG. HUVECs were randomly distributed into six groups with different treatments. A EDU incorporation assays, B tube formation assays, C transwell migrate on assays and D its statistical data, E–H cell cycle distribution and rates of apoptosis in different groups by flow cytometry, I Western Blotting results of key proteins such as PI3Kγ, PIK3R1, P-Akt, and IL-17 in six groups and J its statistical data, K qPCR results of relative miR-21-5p level in the tissues of the six groups, scale bar: 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001