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Table 1 Effects of drug combination treatment on altered parameters of pulmonary function under AngII or BK challenge

From: Protein nanoparticle-induced osmotic pressure gradients modify pulmonary edema through hyperpermeability in acute respiratory distress syndrome

 

Sham

AngII

AngII+S+T+SAR+Gli

BK

BK+S+T+SAR+Gli

Ti(ms)

45.32±8.19

69.57±7.21*

52.15±4.81#

63.17±8.89*

54.55±7.12#

Te(ms)

93.55±12.53

136.23±12.96**

98.18±7.79#

129.07±7.85*

102.26±7.81#

PEF(ml/s)

4.27±0.28

6.61±0.52**

5.17±0.38#

6.37±0.47*

5.22±0.76#

F(BPM)

337.89±34.82

440.81±35.01*

370.45±20.95#

426.06±34.29*

363.07±25.26#

Penh

0.41±0.24

1.08±0.17**

0.72±0.15#

1.23±0.39***

0.64±0.19##

EF50(ml/s)

2.86±0.35

3.78±0.36*

3.38±0.27#

3.55±0.17*

3.12±0.18#

TV(mL)

0.33±0.03

0.24±0.02*

0.29±0.03#

0.25±0.01*

0.28±0.04

RT(ms)

66.28±6.92

49.46±10.51**

59.63±7.12#

53.72±8.03*

59.57±7.46#

EIP(ms)

1.23±0.15

2.88±0.29**

1.62±0.11#

2.43±0.25**

1.33±0.34##

EEP(ms)

10.06±2.69

20.34±2.13***

13.33±1.95###

17.42±2.06**

13.02±1.4###

PIF(ml/s)

8.46±0.38

6.28±0.21*

8.13±0.52#

6.35±0.72*

7.67±0.47#

Sr(ï¼…)

13.06±3.36

24.4±5.11***

17.41±4.72##

26.86±5.24***

15.73±2.25###

  1. Ti inspiration time, Te expiration time, PIF peak inspiration flow, PEF peak expiration flow, EIP end inspiratory pause, EEP end expiratory pause, RT relaxation time, F breathing frequency, Penh enhanced pause, EF50 expiratory flow 50 and TV tidal volume.
  2. Data are shown as the mean ± standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001 for AngII or BK-challenged mice versus saline controls. #p < 0.05. ##p < 0.01. ###p < 0.001 for AngII or BK/drug combination-treated mice versus AngII or BK