Fig. 2

Huc-MSCs-derived exosomes attenuated CFA-induced inflammatory pain and neuroinflammation. a Mice were administered saline or exosomes via intrathecal (i.t.) injection for four successive days, followed by behavior testing or sacrifice at the indicated time points. b, c The protein level of iba1 was tested by western blot in the sham, Con and Exo groups. d Immunofluorescence detected the microglia proliferation in the sham, Con and Exo groups, bar = 50 µm. e Compared with the con group, exosomes increased paw withdrawal threshold and thermal withdrawal latency. Data are presented as mean ± standard deviation (SD). (*P < 0.05, **P < 0.01, ***P < 0.001)