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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition

Fig. 2

Cell viabilities and BBB penetration of Cur and Cur-MNPs. A Results of cell viabilities measured by CCK-8 assay after incubation with varied concentrations of Cur, SDP@Cur, SDP@Cur-CRT, and SDP@Cur-CRT/QSH for 24 h. B Demonstration of the in vitro BBB model tested in a 4 h water-leaking experiment. C Microscopic fluorescence images of Cur and Cur-MNPs treated HT22 cells in the BBB model. D Fluorescence intensity of Cur and Cur-MNPs in HT22 cells in the BBB model measured by FCM. E Fluorescence positive rate of HT22 cells treated by Cur and Cur-MNPs in the BBB model measured by FCM. p = NS indicates nonsignificant. *p < 0.05, **p < 0.01, ***P < 0.001 versus former group

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