Fig. 4

Therapy, diagnosis effect of Cur-MNPs in vivo and 3D displays of the brain after treatment. A Coronal T2*-weighted MRI images of WT and TG mice treated with PBS and Cur-MNPs for 3 months. The dark plaques represented by red arrow mark the β-amyloid protein bound by SDP@Cur-CRT/QSH. B Quantitative analysis of areas occupied by plaques in three consecutive slices. C Quantitative analysis of plaque numbers in three consecutive slices. D Representative 3D images of plaques within the brain or plaques only of each group of mice. E Quantitative analysis of plaque numbers based on 3D plot. F Total volume of plaques of each group based on 3D plots. p = NS indicates nonsignificant. *p < 0.05, **p < 0.01, ***p < 0.001 versus former group, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus TG group