Fig. 7

A-EC/sEVs carrying miR-126-5p blocked the smad1/5/9 signalling pathway in diabetic vascular calcification (DVC) mice. A Immunohistochemistry analysis of Runx2 and BMP2 expression in the thoracic aorta. B Immunohistochemistry analysis of BMPR1B and p-smad1/5/9 in the thoracic aorta. C, D Quantification of Runx2 and BMP2 positive staining area. E, F Quantification of BMPR1B and p-smad1/5/9 positive staining area. Scale bar represents 200 µm and 50 µm respectively. Results are represented as the mean ± SD of three replicates for each group. ^##P < 0.01, ^#P < 0.05