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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Light triggered release of a triple action porphyrin-cisplatin conjugate evokes stronger immunogenic cell death for chemotherapy, photodynamic therapy and cancer immunotherapy

Fig. 5

The ICD cascade generated by NP@Pt-1 promoted the cancer  immune response in vivo. A Gating strategies for flow cytometric analysis of tumor, peripheral lymphocytes and spleen. B Flow cytometry study of DC maturation in tumor-draining lymph nodes. Cells were stained with CD11c antibody. Gating on CD11c+ cells, the percentage of DC maturation as indicated by the portion of CD80+CD86+ cells can be identified. C, D Flow cytometry study of T cell proliferation in spleen (C) and CT26 tumor (D). Cells were stained with CD3 antibody. For gating on CD3+ cells, we identified the percentage of CD8+ T cells as indicated by the portion of CD8+ cells. E Percentage of CD3+CD8+ T cell in spleen and CT26 tumor. F Percentage of CD80+CD86+ cells in tumor-draining lymph nodes. Data are shown as means ± SD, n = 3; *p < 0.05, **p < 0.01

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Journal of Nanobiotechnology

ISSN: 1477-3155

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