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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Immune-regulating strategy against rheumatoid arthritis by inducing tolerogenic dendritic cells with modified zinc peroxide nanoparticles

Fig. 5

ZnCM NPs attenuated RA progression in vivo by targeting splenic DCs. a The bio-distribution pattern in vivo of ZnC, ZnCM NPs in disparate organs based on Zn2+ concentrations. b IVIS imaging of RA mice injected with ZnC, ZnCM NPs retrobular (H: Heart, Li: Liver, S: Spleen, Lu: Lung, K: Kidney). c In vivo Bio-TEM investigations of splenic DCs in RA mice treated with ZnC, ZnCM NPs. The red arrow indicated the in vivo localization of NPs in splenic DCs. d Alleviation of ankle swelling after NPs treatments in RA mice. e Quantitative measurements of swelling paw perimeters weekly. f Pressure–time diagram showed the time course within single stance highlighted by different colors for each limb in RA mice injected with NPs from visual gait analysis system. g Quantitative results of hind limb pressure in RA mice injected with NPs. h Quantitative results of hind-base width in RA mice injected with NPs. i Quantitative results of mean rotate angle in RA mice injected with NPs. LF: left front limb, RF: right front limb; LH: left hind limb, RH: right hind limb. ** indicated the significant difference of p ≤ 0.05 compared with Vehicle, # indicated the significant difference of p ≤ 0.05 compared with Ctrl

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