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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Radiodynamic therapy with CsI(na)@MgO nanoparticles and 5-aminolevulinic acid

Fig. 5

Safety and clearance of CIS@M-F. a H&E staining of tissues harvested from animals treated with regimens detailed in Fig. 4. Scale bar, 100 μm. b Scheme of experimental plans. In a separate experiment, CIS@M-F (1.25 mg/kg) or carrier only (PBS) was i.v. administered into healthy balb/c mice (n = 5). Animals were euthanized after 2 weeks for CBC and serum biochem analyses. In addition, remaining cesium and iodine in tissues were analyzed by ICP-MS. c Summary of CBC and serum biochem results, along with reported normal ranges of the indices. RBC red blood cells, Hgb hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, PLT platelets, MPV mean platelet volume, WBC white blood cells, NEUT neutrophils, LYM lymphocytes, MONO monocytes, EOS eosinophils, BASO basophils, BUN blood urea nitrogen, ALT alanine transaminase. d Iodine (left) and cesium (right) remaining in organ tissues on Day 14. Contents of both elements fell well below 10 ng/g

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