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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Antibacterial metal nanoclusters

Fig. 4

(Reprinted with permission from [91]. Copyright (2019) American Chemical Society)

Surface chemistry modulates the antibacterial activity of metal NCs. a Comparison of antibacterial activities of mercaptopyrimidine analogues mediated AuNCs. Antibacterial activities indicated with MIC (µg/mL). AMP: 4-amino-2-mercaptopyrimidine; DAMP: 4,6-diamino-2-mercaptopyrimidine; AHMP: 4-amino-6-hydroxyl-2-mercaptopyrimidine; DHMP: 4,6-dihydroxyl-2-mercaptopyrimidine. Reprinted with permission from [38]. Copyright (2018) American Chemical Society. b Surface ligand chemistry of AuNCs determines their antimicrobial ability. Reprinted with permission from [40]. Copyright (2018) American Chemical Society. c Schematic illustration of the preparation process of phenylboronic acid-derivative-modified AuNCs by orchestrating the variation of ligands as tunable spectrum antibacterial agents. A/M-AuNCs exert bactericidal activity by interacting with LPS and LTA. d UV-vis spectra of the LPS, LTA, A/M-AuNCs, LPS/A/MAuNCs, and LTA/A/M-AuNCs. The antibacterial activity of A/M-AuNCs at different concentrations against E. coli or S. aureus in the presence of LPS and LTA at concentrations ranging from 0 to 128 µg/mL is plotted in parts e and f, respectively. Reprinted with permission from [88]. Copyright (2018) American Chemical Society. g Intelligent nanoantibiotics (rAgNAs), composed of ultrasmall AgNCs self-assembled with the assistance of acidity-responsive polymeric ligand, can accumulate in the biofilm with enhanced penetration, and can be selectively activated and rapidly release Ag+ in the acidic microenvironment of biofilm for improved therapeutic effect attributed to the acid-triggered disassembling of rAgNAs. h Enhanced accumulation and deep penetration of rAgNAs for the biofilm-amplified bactericidal effect

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