Fig. 7

Schematic illustration of the functional mechanism of Gel-Exo in facilitating recovery after complete SCI. When Gel-Exo was introduced into SCI treatment, mice with SCI showed OPC differentiation and extensive de novo myelination, which could also be simulated by lentivirus-induced VGF overexpression in the absence of Gel-Exo. Following Gel-Exo transplantation or VGF overexpression, SCI mice displayed increased VGF expression in the spinal cord, extensive regeneration of OLs, and improved motor function. The figure was created with BioRender.com