Fig. 3
From: Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy
Combination of tumor embolization therapy and chemotherapy based on tumor-targeting nanoparticles. a The fabrication of chitosan-based polymer NPs and the loading of thrombin and Dox. b Schematic illustration of Th-Dox-NP activity in tumor tissue. c Confocal microscopy images of tumor sections from mice treated with free Dox or Th-Dox-NPs for 8 h. d, e The accumulation of Dox in tumor tissue and the heart. f Vascular disruption and thrombosis formation in tumors treated with Th-Dox-NPs. g Apoptosis in tumors treated with Th-NPs or Th-Dox-NPs at different time points. h–j The therapeutic effect in mice bearing B16-F10 melanomas, MDA-MB-231 human breast xenograft tumors, and MHCC97H human liver tumor [27]. Copyright©2020, Springer Nature