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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Aligned electrospun poly(l-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways

Fig. 4

The effect of electrospun membranes on wound healing in skin defects in mice. A Skin defect healing in mice at different time points. B Line diagram showing skin defect healing in mice at different time points. * indicates a significant difference between the A20 and Con groups, # indicates a significant difference between the A20 and R20 groups. C Statistical analysis of the remaining wound area in the three groups on day 14. (**p < 0.01, ##p < 0.01, ***p < 0.001, n = 5). D, E Immunofluorescence staining of CD86 and CD206 in each group of skin sections on day 7. FG Mean fluorescence intensity of CD86 and CD206 in each group of skin sections on day 7. HI Immunofluorescence staining of CD86 and CD206 in each group of skin sections on day 14. J, K Mean fluorescence intensity of CD86 and CD206 in each group of skin sections on day 14. DAPI (blue) was used to label the nucleus, F4/80 (green) was used to label macrophages, and CD86 or CD206 (red) was used to label M1- or M2-phenotype macrophages, respectively (*p < 0.05, **p < 0.01, *** p < 0.001, n = 3)

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