Fig. 6

The PSD-dependent structural alteration by fullerenol at the synapse in hippocampus. A, B Representative image and statistical analysis of the number of spines, C, D The number of PSD, E, F Western blot and statistical analysis of PSD95 protein, p-CaMKIIα/total CaMKII showed that fullerenol up-regulated the PSD-dependent structures. One-way ANOVA with Tukey-test post hoc analysis. The estimation of mixed effect model used in statistical analysis of the number of spines eliminated the type I error from the random effect. Date were represented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 compared with the control group. ^# p < 0.05, ^### p < 0.001 compared with the lead-exposed group