Fig. 2
From: Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
Effect of endothelial and ECM barriers on nano-drug delivery. A “Tumor-microenvironment-on-chip” (T-MOC) for NP transport assessment. (i) schematic diagram of design principles, (ii) characterization of the effects of NP size on extravasation and interstitial diffusion using T-MOC. Reproduced with permission [77], Copyright 2014, Elsevier publications. B Tumor-vasculature-on-a-chip (TVOC) model to recapitulate the EPR effect, (i) schematic diagram of design principles, (ii) Permeability coefficients for NPs in TVOC. Reproduced with permission [53], Copyright 2018, ACS publications. C 3D colorectal tumor-on-a-chip to assess the nano-drug delivery efficiency, (i) schematic diagram of design principles, (ii) formation of endothelial sprouts in the microfluidic device. Reproduced with permission [54], Copyright 2019, AAAS publications