Fig. 4
From: Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
Targeted tumorous uptake of NDDS in TOCs. A Multiple tumor culture chip (MTC-chip) to assess the cellular uptake of MSNs, (i) schematic diagram of design principles, (ii) comparison of different routes of MSNs administration on the chip with three-way mixing valve inlet, (iii) characterization the effect of administration routes on MSN penetration, (iv) characterization the effect of MSN particle size on MSN penetration. Reproduced with permission [56], Copyright 2019, John Wiley and Sons. B Peristaltic human colon tumor organoids on the microfluidic chip to model the cellular uptake of micelles, (i) schematic diagram of design principles, (ii) micelle uptake in organoids cultured by different methods. Reproduced with permission [57], Copyright 2021, IOP Publishing