From: Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
Models | Advantages | Disadvantages |
---|---|---|
2D cell-culture | Cheap, High-throughput Easy to culture | Only tumor cell lines No TME Morphology and phenotype changes |
3D spheroids | Cell-cell and cell-ECM interaction Physiological morphology | Batch-to batch variation Lack of vascularization and shear stress |
Organoids | Patient-specific cell High heterogeneity | Expensive and difficult to culture Lack of vascularization and shear stress Lack of inherent functions of in situ organs |