Fig. 4

The inhibition mechanism of lung metastasis to local DOX-JQ1@Gel implantion. A In vivo bioluminescence imaging of 4T1-Luc breast cancer mice after treatment 7 and 30 days. Representative H&E staining of lungs collected from untreated and DOX-JQ1@Gel-treated mice after treatment 7 and 30 days. Splenocytes isolated from tumor-bearing control and treated mice were analyzed for the presence of CD4⁺CD44⁺ (B) and CD8⁺CD44⁺ (C) memory T cells. D Corresponding quantification of CD4 and CD8 memory T cells in splenocytes