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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Fig. 1

Schematic diagram of synthesis (a) and application in cancer treatment (b) of CS@P nanoparticles. a Preparation of pH-sensitive Nanoparticles CS@P used to deliver Nr2f6 siRNA to both T cells and tumor cells. b Under NIR laser irradiation, fever temperature (~ 42–45 °C) reveres immunosuppressive TME and activates T cells. Via Nr2f6 siRNA-mediated gene silencing, the pH- triggered nanoparticles CS@P not only suppress HCC cell proliferation and metastasis but also strongly enhance cytokines secretion of activated T cells, such as IL-2, IFN-γ, and TNF-α. The loss of NR2F6 and mild PTT further increase the response rates of established PD-1/PD-L1 checkpoint blockade to suppress primary and distant tumors, and prevent tumor metastasis

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