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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Fig. 5

Immune response of CS@P together with laser and PD-L1 in vivo. a Schematic diagram of the model and therapeutic schedule of primary and distant H22 tumor model. b Primary tumor growth tendency of H22 tumor-bearing mice with various treatments. Tumor sizes were normalized to initial sizes. Error bars stand for ± SD (n = 6). c Primary tumor growth curves in the H22 tumor-bearing BALB/c mice (n = 6). d Representative flow cytometry plots showing different groups of T cells in primary tumors (gated on CD3+ T cells) after indicated treatments. e The Treg flow cytometry analysis in primary tumors after various treatments. f Representative flow cytometry plots showing matured DC cells in primary tumors after various treatments. g Immunohistochemical staining of NR2F6 and PD-L1 in primary tumor sections (top). H&E and TUNEL examination of tumor sections (bottom). Scale bar: 100 µm. *P < 0.05, **P < 0.01, and ***P < 0.001

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