Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

Afarid, Mehrdad; Mahmoodi, Shirin; Baghban, Roghayyeh

doi:10.1186/s12951-022-01567-7

Journal of Nanobiotechnology

Table 2 FDA approved and under clinical trial nanomedicine for ocular diseases

From: Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

Trade name	Drug/Bioactives		Target tissue	Target indication (Use)	Delivery system	Route	FDA Approval Status	Refs.
Durezol®		Difluprednate Ophthalmic Emulsion 0.05%	Mainly anterior segment of the eye, anterior chamber, cornea conjunctiva	Anterior uveitis	Nanoemulsion	Eye drop	Approved	[274]
Restasis®		Cyclosporine ophthalmic emulsion 0.05%	Cornea and Tear film	Dry eye	Nanoemulsion	Oral, intravenous (IV), eye drop	Approved	[275]
Ikervis®	Ciclosporin ophthalmic emulsion 0.1%		Cornea and Tear film	Dry eye	Nanoemulsion	Eye drop	Approved	[276]
Cequa®	Cyclosporine ophthalmic solution 0.09%		Cornea and Tear film	Dry eye	Micelle	Eye drop	Approved	[277]
Cyclokat®	Cationic emulsion 0.1%		Cornea and Tear film	Dry eye	Cationic nanoemulsion	Eye drop	Approved	[278]
Lacrisek®	Vitamin A palmitate, vitamin E		Cornea and Tear film	Dry eye	Liposomal spray	Eye drop	Approved	[279]
Artelac Rebalance®	Lubricant		Cornea and Tear film	Dry eye	Liposomal eyedrops	Eye drop	Approved	[280]
Ozurdex	Dexamethasone biodegradable implant		Vitreous, Retina, Choroid	Macular edema, Non-infectious uveitis	Implant	Intravitreal injection	Approved	[235]
Iluvien	Fluocinolone acetonide nonbiodegradable implant		Vitreous, Retina, Choroid	Diabetic macular edema	Implant	Intravitreal injection	Approved	[236]
Visudyne	Verteporfin		Retina, Choroid	Wet AMD, Choroidal neovascularization, Central Serous Chorioretinopathy	Liposomal injection	Intravenous	Approved	[281]
Macugen®	Pegaptanib		Retina Choroid	Wet AMD	Liposome	Intravitreal injection	Approved	[282]
Triesence	Triamcinolone acetonide suspension		Vitreous, Retina, Choroid	Macular edema	Microparticle	Intravitreal injection	Approved	[194, 237]
AzaSite ®	Azithromycin Ophthalmic 1% Solution		Conjunctiva, cornea	Antimicrobial	Micelle	Eye drop	Approved	[283]
Trivaris	Triamcinolone acetonide suspension		Vitreous, Retina, Choroid	Uveitis	Microparticle	Intravitreal injection	Approved	[194, 237]
Kenalog	Triamcinolone acetonide suspension		Vitreous, Retina, Choroid	Macular edema	Microparticle	Intravitreal injection, Suprachoroidal injection	Approved	[194, 237]
Retisert	Fluocinolone acetonide nonbiodegradable implant		Vitreous, Retina, Choroid	Uveitis	Implant	Intravitreal injection	Approved	[238]
TLC399	ProDex		Vitreous, Retina, Choroid	Macular edema	Pro Dex	Intravitreal injection	Phase II	[239]
POLAT-001	latanoprost-coated liposome		Anterior segment	Glaucoma	Liposome	Subconjunctival injection	Phase II	[284]
SYSTANE®	Propylene glycol-based nanoemulsion		Cornea and Tear film	Dry eye	Nanoemulsion	Eye drop	Phase IV	[285]
ENV 515	Travoprost extended release (XR)		Anterior segment	Glaucoma	Nanoparticles	Intracameral Implant	Phase II	[286]
AR-13503	AR-13503 implant alone and in combination with aflibercept		Retina, Choroid	Neovascular AMD and diabetic macular edema	Intravitreal implants	Intravitreal injection	Phase I	[3, 240]
AR-1105	Dexamethasone intravitreal implant		Retina, Choroid	AMD and diabetic macular edema	Intravitreal implants	Intravitreal injection	Phase II	[3]
Taxol	Paclitaxel albumin-stabilized nanoparticle formulation		Retina, Choroid	Intraocular melanoma	Nanoparticles	Intravenous injection	Phase II	[241]
GB-102	Sunitinib malate		Retina, Choroid	AMD	Nanoparticles	Intravitreal injection	Phase I	[242]
KPI-121	1 and 0.25% loteprednol etabonate		Anterior segment	Conjunctiva, cornea, tear film	Mucus penetrating particles	Eye drop	Phase III	[243]
OCS-01	Dexamethasone Cylcodextrin Nanoparticle Ophthalmic Suspension 1.5% mg/ml		Anterior segment, Retina	Control of Inflammation, Diabetic Macular Edema	Nanoparticle	Eye drop	Phase II	[244]

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ISSN: 1477-3155

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