Fig. 9
From: Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
Reprinted (adapted) with permission from [162]. Copyright 2022 American Chemical Society
Enzyme-responsive CRISPR-Cas9 delivery nanoformulations. AÂ Design and immunotherapeutic functions of PUN@Cas-PT: fabrication and the programmable unlocking process of PUN@Cas-PT in response to MMPs, HAase, and ROS, and schematic illustration of the utilization of PUN@Cas-PT for efficient multitargeted ICB therapy in vivo. Reproduced with permission [154]. BÂ Schematic illustration of the design of the CRISPR-Cas9 gene-editing system loaded multifunctional nanoplatform (GTLARC: gold nanorod modified with TAT and linker-Apt to load sgRNA/Cas9 complex) and targeted gene editing and combined tumor therapy based on the multifunctional nanoplatform.