Fig. 4

NEX enhances the targeting of hucMSC-sEVs and alleviates cisplatin-induced acute renal injury in vivo. a Small animal in vivo imaging was used to detect the distribution of three kinds of vesicles labeled with DIL dye in the cisplatin-induced acute kidney injury (AKI) mouse model. b Schematic diagram of three vesicles intervening in acute kidney injury induced by cisplatin. c HE staining was used to determine the pathological changes of renal tissues in the AKI model after three kinds of vesicle administration (scale bars: 100 μm and 200 μm). d, e Biochemical experiments were applied to evaluate the renal and liver function of the AKI model after three kinds of vesicle administration