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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K/Akt/mTOR signaling pathway

Fig. 6

KP-SeNPs induce autophagy and apoptosis by inhibiting the PI3K/Akt/mTOR pathway. A Gene and protein B, C expression of PI3K/Akt/mTOR pathway markers and downstream effectors in AGS cells. Cells were treated with KP-SeNPs (150, 200 μg/mL) and KP-RE (150, 200 μg/mL) for 24 h. D Gene and protein (E, F) expression levels of PI3K/Akt/mTOR pathway markers and downstream effectors in AGS cells treated with KP-SeNPs (200 μg/mL), 740Y-P (30 μM), and KP-SeNPs (200 μg/mL) in combination with 30 μM 740Y-P for 24 h. KP-SeNPs promote autophagy through the PI3K/Akt pathway. The autophagy-related gene (G) and protein (H, I) expression levels of LC3 II/I and p62. KP-SeNPs induce apoptosis in AGS cells through the PI3K/Akt pathway. The apoptosis-related gene (J) and protein (K, L) expression of Bax, Bcl-2, and caspase 3. The images of western blots were measured using Image J. The asterisks in the graph represent significant differences between sample and control. *p < 0.05, **p < 0.01, ***p < 0.001, compared with control

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