Fig. 2

Fabrication and characterization of STAMP and blank microneedle patch. A Schematic diagram of manufacture process with a PDMS mold. B Designed model of the STAMP. The purple arrow indicated the imperfection. C Macroscopic view of the master mold. D Image of the PDMS mold under the stereomicroscope. Scale bar, 1 mm. E Stereomicroscopic image of the blank CA-CMC microneedle patch. Scale bar, 1 mm. F Stereomicroscopic image of STAMP with lyophilized Schistosoma japonicum eggs, which were obviously located on the tip as indicated by the purple arrow. Scale bar, 1 mm. G Stereomicroscopic image of a STAMP after penetration and tip-base separation. Scale bar, 1 mm. H SEM image of the blank CA-CMC microneedle patch. Scale bar, 1 mm. I SEM image of STAMP. Notably, the eggs were loaded in the tip. Scale bar, 1 mm. J Microscopic image of purified Schistosoma japonicum eggs. Scale bar, 100 μm