Fabrication of multifunctional metal–organic frameworks nanoparticles via layer-by-layer self-assembly to efficiently discover PSD95-nNOS uncouplers for stroke treatment

Table 1 Comparison of different immobilization materials on loading efficiency

Materials	Main reactant	Main reactant	Loading efficiency (%)
Magnetic Fe-MOF	Fe₃O₄	2-Aminoterephthalic acid	92.26 ± 0.55
Fe-COOH-MOF	Fe₃O₄-COOH	2-Aminoterephthalic acid	48.06 ± 1.83
UiO-66-NH₂	ZrCl₄	2-Aminoterephthalic acid	41.90 ± 1.03
Cu-BDC	Cu(NO₃)₂·2.5H₂O	2-Aminoterephthalic acid	33.72 ± 1.02
HKUST-1	Cu(NO₃)₂·2.5H₂O	Trimesic acid	63.70 ± 3.38
Zr-fum	ZrCl₄	Fumaric acid	50.66 ± 1.32
SBA-15	Pluronic P123	Tetraethyl orthosilicate	80.67 ± 0.68

ISSN: 1477-3155