Fig. 5From: Tumor-derived small extracellular vesicles: potential roles and mechanism in gliomaThe extracellular matrix in GBM tumorigenesis. The features of extracellular matrix in normal brain are low overall density and stiffness and absence of neurodevelopmental proteins. The features of extracellular matrix in GBM are increased overall density and stiffness, presence of oncofetal protein isoforms, and promotion of invasion and angiogenesisBack to article page