Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Table 1 Overview of TEXs cargos and their biological effects in TME

Donor cell	Exosomal cargos	Receiving cell	Biological effects	References
CD133 + U87	miRNAs	Vascular system cells	Promote angiogenic response	[74]
U251	/	hBMSCs	Promote proliferation, migration, invasion, cell cycle and glycolysis	[155]
GBM cells	CD73	T cells	Inhibit cell cycle and proliferation	[75]
Hypoxic glioma cells	miR-10a and miR-21	MDSCs	Target RORA and PTEN Induce MDSCs amplification and activation	[76]
GBM cells	miR-214-5p	primary microglia	Target CXCR5 Promote inflammatory response	[79]
GBM cells	miR-1246	M2 macrophage	Target TERF2IP/STAT3/NF-κB Induced M2 macrophage polarization	[80]
GBM cells	miR-155-3p	M2 macrophage	Target IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 Induced M2 macrophage polarization	[81]
Glioma cells	circNEIL3	macrophage	Induce immunosuppressive properties	[82]

ISSN: 1477-3155