From: Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma
Donor cell | Exosomal cargos | Receiving cell | Biological effects | References |
---|---|---|---|---|
CD133 + U87 | miRNAs | Vascular system cells | Promote angiogenic response | [74] |
U251 | / | hBMSCs | Promote proliferation, migration, invasion, cell cycle and glycolysis | [155] |
GBM cells | CD73 | T cells | Inhibit cell cycle and proliferation | [75] |
Hypoxic glioma cells | miR-10a and miR-21 | MDSCs | Target RORA and PTEN Induce MDSCs amplification and activation | [76] |
GBM cells | miR-214-5p | primary microglia | Target CXCR5 Promote inflammatory response | [79] |
GBM cells | miR-1246 | M2 macrophage | Target TERF2IP/STAT3/NF-κB Induced M2 macrophage polarization | [80] |
GBM cells | miR-155-3p | M2 macrophage | Target IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 Induced M2 macrophage polarization | [81] |
Glioma cells | circNEIL3 | macrophage | Induce immunosuppressive properties | [82] |