Table 3 Overview of TEXs cargos and their biological effects in chemoresistance
From: Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma
Donor cell | Exosomal cargos | Receiving cell | Biological effects | References |
|---|---|---|---|---|
Z-M fused GBM cells | / | GBM cells | Promote cell migration, invasion, neurosphere growth, angiogenesis and TMZ resistance | [91] |
TMZ resistant GBM cells | Cx43 | TMZ sensitive GBM cells | Promote cell migration, invasion and TMZ resistance | [92] |
Glioma stem cells | miRNAs | Glioma cells | Target PTEN/Akt signal pathway Promote cell migration and invasion | [93] |
TMZ resistant GBM cells | MIF | TMZ sensitive GBM cells | Target TIMP3/PI3K/AKT signal pathway Promote TMZ resistance | [95] |
U87MG | miR-221 | SHG-44 | Target RELA/miR-221/DNM3 signal pathway Promote cell proliferation, migration and TMZ resistance | [96] |
TMZ resistant GBM cells | miR-151a | TMZ sensitive GBM cells | Target miR-151a/XRCC4/DNA signal pathway Promote TMZ resistance | [97] |
TMZ resistant GBM cells | miR-1238 | TMZ sensitive GBM cells | Target miR-1238/CAV1/EGFR signal pathway Promote TMZ resistance | [156] |
TMZ resistant GBM cells | SBF2-AS1 | TMZ sensitive GBM cells | Target miR-151a-3p/XRCC4 Promote TMZ resistance | [99] |
TMZ resistant GBM cells | miR-25-3p | TMZ sensitive GBM cells | Target miR-25-3p/FBXW7/c-myc/cyclin E Promote cell proliferation and TMZ resistance | [100] |
GBM cells | lnc-TALC | TAM | Target ENO1/p38/MAPK Promote M2 polarization of microglia and TMZ resistance | [101] |
TMZ resistant GBM cells | circNFIX | TMZ sensitive GBM cells | Target miR-132 Promote cell migration, invasion and TMZ resistance | [137] |
TMZ resistant GBM cells | circ-HIPK3 | TMZ sensitive GBM cells | Target miR-421/ZIC5 Promote cell growth, invasion and TMZ resistance | [102] |
TMZ resistant GBM cells | circ-007208 | TMZ sensitive GBM cells | Target miR-1252-5p/ALKBH5/NANOG Promote cell growth, invasion and TMZ resistance | [104] |
TMZ resistant GBM cells | has_circ_0042003 | TMZ sensitive GBM cells | Promote cell TMZ resistance | [105] |