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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Mechanisms of chemotherapeutic resistance and the application of targeted nanoparticles for enhanced chemotherapy in colorectal cancer

Fig. 4

(Reproduced with permission from [146]. © 2021 Elsevier B.V. All rights reserved)

pH-sensitive hydrazone bonds attached doxorubicin to mPEG-based diblock copolymers. a Rates of Doxo release from different ratios of Leu and Glu copolymers bound to mPEG at varying pH conditions; Doxo release profile of mPEG5kDa-(Doxo-hydGlu)16; b Doxo release profile of mPEG5kDa-b-[(Dox-hydGlu)6-r-Leu10]; c Confocal microscopy images of CT26 cells and nanodrug after 2 h incubation and a further 4 h incubation. Nanodrug delivery into the cells and cleavage of the hydrazone bond in an acidic lysosomal environment resulted in Doxo release

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