Fig. 2

Protective effects of nanoFe treatment in septic mice. A Survival curves indicating the survival of mice after treatment of different concentrations of nanoFe (5, 10, and 20 mg/kg). Mortality was observed within 96 h. (n = 10 for each group). B The sepsis score recorded after treatment with nanoFe (10 mg/kg) and nanoFe (20 mg/kg) (n = 10 for each group). C The sepsis score of Sham, CLP, and nanoFe (20 mg/kg) + CLP mice (n = 6 for each group). D The anal temperature (n = 6 for each group). E Blood biochemical parameters (n = 6 for each group). F Blood routine parameters (n = 6 for each group). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001 vs. Sham or vs. CLP (panel A and C-F) or vs. nanoFe (10 mg/kg) + CLP (panel B); ns, non-significant. Statistical analysis of B was performed using t-test. Statistical analysis of the other data was used ANOVA